Comparison of bone marrow biopsy and smear efficacy in patients with multiple myeloma.
- Author:
Ji-Ying SU
1
;
Yin TAO
;
Yi-Zhi LIU
;
Li-Yu ZHOU
;
Lian-Ping YANG
;
Hong LIU
;
Cun-Kang CHANG
Author Information
1. Department of Hematology, Shanghai Jiaotong University Sixth People Hospital, Shanghai 200233, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Biopsy;
methods;
Bone Marrow;
pathology;
Bone Marrow Examination;
methods;
Female;
Humans;
Male;
Middle Aged;
Multiple Myeloma;
pathology
- From:
Journal of Experimental Hematology
2012;20(6):1389-1391
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to explore the significance of the bone marrow biopsy for the diagnosis of multiple myeloma. Bone marrow smears and bone marrow biopsy originated from 279 cases of multiple myeloma were detected and compared in term of bone marrow hyperplasia, bone marrow plasma cell infiltration, proliferation mode, pathological changes in the bone marrow stroma and myelofibrosis. The results indicated that the levels of proliferation in bone marrow biopsy was significantly higher than that in bone marrow smears. Plasma cell proliferation mode in bone marrow biopsy was not completely consistent with the proportion of plasma cells in bone marrow smears. The myelofibrosis level displayed influence on the consistency of the proliferation between bone marrow smears and biopsies. It is concluded that as compared with bone marrow smears the bone marrow biopsy can more accurately reflect the levels of bone marrow hyperplasia and bone marrow plasma cell infiltration, proliferation mode and so on. Bone marrow biopsy is valuable for multiple myeloma diagnosis.
