Expression of MCL-1 and BAK proteins in nutritional anemia and its clinical significance.
- Author:
Yu-Jie GUO
1
;
Yan WANG
;
Feng-Ru LIN
Author Information
1. Department of Hematology, the Second Hospital Affiliated to Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China.
- Publication Type:Journal Article
- MeSH:
Anemia;
metabolism;
pathology;
Apoptosis;
Case-Control Studies;
Humans;
Malnutrition;
metabolism;
pathology;
Myeloid Cell Leukemia Sequence 1 Protein;
metabolism;
bcl-2 Homologous Antagonist-Killer Protein;
metabolism
- From:
Journal of Experimental Hematology
2012;20(6):1419-1422
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the relation of MCL-1 and BAK proteins with incidence and development of nutritional anemia (NA) and their clinical significance. The MCL-1 and BAK protein levels in serum of 66 patients with NA were determined by using ELISA. Eighteen healthy people were randomly selected as normal controls. The results indicated that: (1) as compared with normal control group, the expression level of MCL-1 protein in 3 NA groups (iron-deficiency anemia, macrocytic anemia, mixed anemia) significantly decreased (P < 0.001), while the expression level of BAK protein obviously increased (P < 0.001), but the expression level of MCL-1 and BAK proteins among 3 NA groups showed no obvious differences; (2) the MCL-1 protein expression level increased and BAK protein expression level decreased in 3 NA groups after treatment (P < 0.05). (3) there was negative correlation of expression levels of MCL-1 protein with BAK protein in NA group (r = -0.858 P < 0.05). It is concluded that the MCL-1 and BAK proteins may play an important role in the incidence and development of NA, and can be used as the assist index for defining diagnosis and evaluate prognosis of NA.
