Frequency and linkage disequilibrium of specific HLA-DR and HLA-DQ genes in Chinese Han population.
- Author:
Su-Xia YANG
1
;
Zhi-Fei HU
;
Qiang ZU
;
Jin-Shan LU
;
Xu ZHANG
;
Jun DONG
Author Information
1. Department of Urology, Chinese PLA General Hospital, Beijing 100853, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Asian Continental Ancestry Group;
genetics;
Gene Frequency;
Genotype;
HLA-DQ Antigens;
genetics;
HLA-DR Antigens;
genetics;
Haplotypes;
Humans;
Kidney Transplantation;
Linkage Disequilibrium
- From:
Journal of Experimental Hematology
2012;20(6):1463-1468
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the distribution feature of HLA-DR/DQ gene linkage disequilibrium in Chinese Han population and to improve the accuracy of HLA matching results. Genotyping of HLA-DR and HLA-DQ gene locus was performed using PCR-SSP typing in Chinese Han population receiving kidney transplantation. The results showed that there were 29 new linkage combinations in 1799 patients, in which DR13-DQ5, DR11-DQ8 and DR8-DQ8 were discovered for 11, 8 and 7 times respectively while DR9-DQ8, DR12-DQ6 and DR14-DQ4 were both discovered for 6 times. The linkage disequilibrium parameters of these haplotypes were negative, showing that these linkages were uncommon. It is concluded that this study not only enriches the classical HLA-DR/DQ linkage combinations, but also indicates the national relevance of combination distribution, and it has great importance in improving the accuracy of HLA matching experiments and reducing unnecessary repeated work.
