Expression of MCL-1 and microRNA-29a in extranodal NK/T-cell lymphoma tissue.
10.7534/j.issn.1009-2137.2013.01.020
- Author:
Hao-Bo HUANG
1
;
Rong ZHAN
;
Shun-Quan WU
;
Zhen-Zhen XU
;
Li-Ping FAN
Author Information
1. Department of Transfusion, Fujian Medical University, Fuzhou, Fujian Province, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Female;
Gene Expression Regulation, Neoplastic;
Humans;
Lymphoma, Extranodal NK-T-Cell;
genetics;
pathology;
Male;
MicroRNAs;
genetics;
Middle Aged;
Myeloid Cell Leukemia Sequence 1 Protein;
genetics;
Young Adult
- From:
Journal of Experimental Hematology
2013;21(1):95-98
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to explore the expression level and correlation of MCL-1 and miR-29a in extranodal NK/T-cell lymphoma (ENKTCL) tissue. Maxvision immunohistochemistry technique and real time fluorescent quantitative PCR were used to detect the expression level of MCL-1 and miR-29a in tissue of 20 patients with ENKTCL and 10 patients with proliferative lymphadenitis, respectively. The results showed that the expression of MCL-1 protein were higher in patients with ENKTCL than that in patients with proliferative lymphadenitis, but there were no significant correlation between MCL-1 overexpression and age, sex, Ann Arbor stage and International Prognostic Index (IPI), respectively. Correlation analysis indicated that there was significant negative correlation between miR-29a expression and MCL-1 expression (r = -0.59, P = 0.016). It is concluded that miR-29a may target MCL-1 gene, regulate its expression, then participate in tumorigenesis and development of ENKTCL.
