Sumoylation and its role in hematological disease.
10.7534/j.issn.1009-2137.2013.01.044
- Author:
He-Jing HUANG
1
;
Jian HOU
Author Information
1. Department of Hematology, The Second Military Medical University, Shanghai, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Hematologic Diseases;
pathology;
therapy;
Humans;
Sumoylation
- From:
Journal of Experimental Hematology
2013;21(1):218-221
- CountryChina
- Language:Chinese
-
Abstract:
Small ubiquitin-related modifier (SUMO) can be covalently attached to target proteins and thereby plays a crucial role in regulating the normal functions of cells, such as protein-protein interaction, subcellular localization, DNA repair, cell cycle and transcription factor regulation. Several lines have implicated that sumoylation is important in disease occurrence and development. This brief review will focus on some recent findings about the roles of sumoylation in the etiology and treatment of hematological malignancies.
