Research progress of mesenchymal stem cell-derived microvesicle.
10.7534/j.issn.1009-2137.2013.01.046
- Author:
Xiao-Qing WANG
1
;
Xiao-Jian ZHU
;
Ping ZOU
Author Information
1. Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cell-Derived Microparticles;
metabolism;
Humans;
Mesenchymal Stromal Cells;
metabolism;
MicroRNAs;
metabolism
- From:
Journal of Experimental Hematology
2013;21(1):227-230
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cell-derived microvesicle (MSC-MV) is a membrane secretory system which includes microparticle and exosome, and MSC-MV is released by MSC in resting or activated state. MSC-MV selectively package the biological active substances such as lipids, proteins, mRNA and miRNA but not loads them randomly. It has definitive effect of reducing tissue injury, promoting morphological and functional recovery of the injured tissue, and this effect is probably mediated by miRNA. What is more, the MSC-MV may also possess the biological function of immunological regulation, modulation of cell growth and differentiation. The generation, constitution, and function of MSC-MV are reviewed in this article.
