Multidrug resistance-related proteins and their relationship with acute leukemia.
10.7534/j.issn.1009-2137.2013.01.048
- Author:
Zhi LI
1
;
Bao-An CHEN
Author Information
1. Department of Hematology and Oncology, Southeast University Medical School, Nanjing, Jiangsu Province, China.
- Publication Type:Journal Article
- MeSH:
Acute Disease;
Drug Resistance, Multiple;
genetics;
Drug Resistance, Neoplasm;
genetics;
Genes, MDR;
Humans;
Leukemia;
genetics;
Proteins;
genetics
- From:
Journal of Experimental Hematology
2013;21(1):236-240
- CountryChina
- Language:Chinese
-
Abstract:
Multidrug resistance-related proteins (MRP) are identified as ATP-dependent efflux pumps, the expression abnormality of which has close relationship with multidrug resistance (MDR) in a variety kinds of malignancies, leading to the failure of chemotherapy. The relationship between the expression of MRP and acute leukemia remains to be proved, since experiments and clinical researches are still insufficient. In this article, the structure, distribution, function, and relation of MRP to MDR and prognosis of acute leukemia are reviewed.
