Recent studies on PI3K/AKT/mTOR signaling pathway in hematopoietic stem cells.
10.7534/j.issn.1009-2137.2013.01.050
- Author:
Ying-Chi ZHANG
1
;
Tao CHENG
;
Wei-Ping YUAN
Author Information
1. Chinese Academy of Medical Sciences, Tianjin, China.
- Publication Type:Journal Article
- MeSH:
Hematopoietic Stem Cells;
Humans;
Phosphatidylinositol 3-Kinases;
metabolism;
Proto-Oncogene Proteins c-akt;
metabolism;
Signal Transduction;
TOR Serine-Threonine Kinases;
metabolism
- From:
Journal of Experimental Hematology
2013;21(1):245-249
- CountryChina
- Language:Chinese
-
Abstract:
PI3K/AKT/mTOR signaling pathway plays an essential role in the growth, proliferation and survival of various type of cells and also hematopoietic stem cells (HSC). Aberrant activation of PI3K/AKT/mTOR signaling pathway leads to exhaustion of HSC, while the inhibition of PI3K/AKT/mTOR signaling pathway results in blocking of B cell differentiation. This article reviews the latest advances on the role of key components involved in the PI3K/AKT/mTOR signaling pathway, including PI3K, AKT, mTOR, FoxO and GSK-3 in HSC.
