Drug resistance of leukemic stem cells mediated by hedgehog signaling pathway.
10.7534/j.issn.1009-2137.2013.01.051
- Author:
Ping-Fang XIA
1
;
Qi PENG
;
Miao-Rong SHE
Author Information
1. Department of Hematology, Guangdong Provincial Academy of Medical Sciences, Guangzhou, China.
- Publication Type:Journal Article
- MeSH:
Drug Resistance, Neoplasm;
Hedgehog Proteins;
metabolism;
Humans;
Leukemia;
metabolism;
Neoplastic Stem Cells;
drug effects;
Signal Transduction
- From:
Journal of Experimental Hematology
2013;21(1):250-253
- CountryChina
- Language:Chinese
-
Abstract:
Drug resistance and relapse are the major challenge for current treatment of acute leukemia. It is critical for ultimately curing leukemia to overcome chemoresistance of leukemic stem cells (LSC) and to eradicate LSC. Recent studies have found that abnormal activated Hedgehog (HH) signaling pathway plays an important role in a wide variety of tumors and regulates multi-drug resistance of LSC. This review briefly summarizes the molecular mechanism of HH signal pathway inducing drug resistance of LSC and leading to novel strategies for eradicating LSC.
