Role of prostate stem cell antigen in human pancreatic carcinoma: a tissue microarray-based study.
- Author:
Wen-bin YANG
1
;
Feng CAI
;
Chuan-tao CHENG
;
Gang CAO
;
Zhao-yin QING
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Antigens, Neoplasm; genetics; metabolism; Carcinoma, Ductal; immunology; metabolism; Female; GPI-Linked Proteins; genetics; metabolism; Humans; Male; Middle Aged; Neoplasm Proteins; genetics; metabolism; Pancreatic Neoplasms; immunology; metabolism; Tissue Array Analysis; methods
- From: Journal of Southern Medical University 2009;29(10):2135-2137
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of prostate stem cell antigen (PSCA) in human pancreatic carcinoma and explore its role in the oncogenesis of pancreatic cancer.
METHODSA pancreatic carcinoma tissue microarray was constructed, which contained 10 normal adult pancreas tissues, 12 chronic pancreatitis tissues and 78 pancreatic carcinomas. Immunohistochemistry was employed to detect the expression of PSCA, and the relation between PSCA expression and the clinicopathological factors of pancreatic carcinoma was analyzed.
RESULTSThe positivity rate of PSCA in pancreatic carcinoma was 79.5% (62/78), and PSCA staining was more intense in the malignant cells than in the benign cells (chi2=15.81, P<0.005) and chronic pancreatitis tissues (chi2=11.33, P<0.005). No obvious association was found between PSCA expression and the other variables of pancreatic carcinoma (including gender, age at surgery, tumor grade, and TNM stages).
CONCLUSIONThe expression of PSCA can be related to the development of pancreatic cancer, but not to the clinicopathological factors of the tumor.
