Inhibitory effects of COX-2 inhibitor on migration of human tongue squamous cell carcinoma Tca8113 cells.
- Author:
Qiu-Ju HUO
1
;
Wei-Zhong LI
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Squamous Cell; pathology; Celecoxib; Cell Line, Tumor; Cell Movement; drug effects; Cyclooxygenase 2 Inhibitors; pharmacology; Humans; Pyrazoles; pharmacology; Sulfonamides; pharmacology; Tongue Neoplasms; pathology
- From: Journal of Southern Medical University 2009;29(11):2194-2196
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the role of COX-2 inhibitor celecoxib in inhibiting the migration of human tongue squamous cell carcinoma Tca8113 cells.
METHODSThe effects of celecoxib on Tca8113 cell migration were tested using scrape motility assay, cell-matrix adhesion assay and Boyden chamber motility assay.
RESULTSFollowing a 24-hour incubation with 10 and 20 micromol/L celecoxib, the migration of Tca8113 cells was significantly decreased (Plt;0.05). Celecoxib treatment for 24 h also resulted in significantly decreased adhesion of Tca8113 cells on Fn-coated surface in a dose-dependent manner.
CONCLUSIONCOX-2 inhibitor celecoxib can inhibit Tca8113 cell migration, the mechanism of which awaits further investigation.
