OBJECTIVETo investigate the dynamic changes of plasma tissue factor (TF) and tissue factor pathway inhibitor-1 (TFPI-1) and their significance in patients with multiple traumas.

METHODSThe plasma levels of TF, TFPI-1 and D-dimer were detected using enzyme-linked immunosorbent assay in patients on the first, second and third days after multiple traumas, with 25 healthy adults as the normal control.

RESULTSThe levels of plasma TF and D-dimer increased on the first day, and reached the peak value on the second day, but TFPI-1 decreased with the passage of time. Significant differences were found in the levels of plasma TF between the multiple trauma patients (on the first, second, third posttrauma days) and the control group (P<0.01). Significant differences were also found in plasma TFPI-1 and D-dimer between the patients (on the second and third posttrauma days) and the control group (P<0.05).

CONCLUSIONCoagulation dysfunction and secondary fibrinolysis occur in the early stage of multiple traumas. Dynamic detection of plasma TF, TFPI and D-dimer is beneficial for understanding the degree of diffuse intravascular coagulation and inflammation after the trauma and can be used as the reference indexes for clinical diagnosis and therapy.