Study on metronidazole resistance to Helicobacter pylori from three populations with different ethnics in Yunnan.
- Author:
Yue-Yan HU
1
;
Zeng-Fen ZHOU
;
Qiong NAN
;
Hai-Yan JIANG
;
Lei ZHANG
;
Xiao-Yan LI
;
Li-Ping DUAN
;
Ya-Rong CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; China; ethnology; Chronic Disease; Drug Resistance, Bacterial; Female; Gastritis; microbiology; Helicobacter Infections; drug therapy; Helicobacter pylori; drug effects; Humans; Male; Metronidazole; pharmacology; therapeutic use; Middle Aged; Peptic Ulcer; microbiology
- From:Chinese Journal of Epidemiology 2004;25(11):986-988
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the prevalence of Helicobacter pylori (H.pylori) resistance to metronidazole among three populations in Yunnan.
METHODSSusceptibilities to metronidazole among 109 H. pylori strains (33 H. pylori strains from Han, 31 H. pylori strains from Bai and 45 H. pylori strains from Naxi ethnic populations) were tested by Epsilometer test (E-test).
RESULTSIn 109 H. pylori strains, the overall metronidazole resistance rate was 67.89%. There were no significant difference in the metronidazole resistant rates of H. pylori among Han, Bai, Naxi populations Yunnan in terms of the distribution on age and upper gastroduodenal diseases. In the facet of gender, metronidazole resistant rate of H. pylori was significantly lower in Han males than in females (chi2=5.304, P=0.027), but not seen in the Bai or Naxi peoples.
CONCLUSIONMetronidazole resistance rate of H. pyloriin Yunnan was high, but no significant difference was found among Han, Bai, Naxi peoples in the province.
