A new statistical method on familial correlation dealing with family data from case-control studies.
- Author:
Yan-hui GAO
1
;
Qing-wu JIANG
;
Xue-fu ZHOU
;
Bao-guo DING
;
Ru-hong WANG
;
Gen-ming ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Bias; Case-Control Studies; China; epidemiology; Data Interpretation, Statistical; Epidemiologic Methods; Family Health; Female; Humans; Liver Neoplasms; epidemiology; genetics; Logistic Models; Male; Odds Ratio; Ovarian Neoplasms; epidemiology; genetics; Risk Factors
- From: Chinese Journal of Epidemiology 2004;25(11):992-996
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThis paper presents a statistical method of familial correlation on family data from case-control studies.
METHODSMarginal mean models of the probands and the relatives conditional on the proband's disease status, as well as the marginal association model of the relatives were modeled integrately. Conditional odds-ratio and marginal odds-ratio were used to measure the familial correlation.
RESULTSThe parameter's interpretation in the model was in accordance with sample characteristics. This method is more efficient due to making fully use of information of the probands and relatives. In addition, the method has all advantages of GEE2.
CONCLUSIONThe method in this paper efficiently and conveniently analyzes the family data from case-control studies to estimate the familial correlation on disease.
