Influence on rat intestinal absorption of huanglian alkalis after match-pair of huanglian-wuzhuyu.
- Author:
Wan-jing SUN
1
;
Yu-jie ZHANG
;
Nan YAO
;
Hao JIANG
;
Qi WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drugs, Chinese Herbal; pharmacokinetics; pharmacology; In Vitro Techniques; Intestines; drug effects; Male; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2008;33(22):2614-2616
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo research effect of Wuzhuyu on Huanglian intestinal absorption and to provide some basic principle of match-pair of huanglian-rougui.
METHODThe rat everted gut sac method as well as non everted gut sac method was applied to investigate the influence of Wuzhuyu on Huanglian intestinal absorption.
RESULTThe content of each alkalis in Huanglian was decreasing with the comptibale ration increase, and the intestinal absorption had been improved in some degree. The intestinal absorption of Huanglian alkalis reached the highest level when match-pair ration of huang Lian-rougui was 6: 1.
CONCLUSIONThe chemical reaction in the progress of extraction and the intestinal absorption of huanglian alkalis were the key factors of match-pair of huanglian-wuzhuyu.
