Effect of gualou xiebai (GLXB) decoction on platelet-derived growth factor BB (PDGF-BB) expression in lungs from bleomycin A5 induced pulmonary fibrosis in rats.
- Author:
Rui-qin LI
1
;
Hong XIAO
;
Rui ZHANG
;
Wei LI
;
Jian-ping SONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bleomycin; analogs & derivatives; pharmacology; Drugs, Chinese Herbal; pharmacology; Female; Gene Expression; drug effects; Immunohistochemistry; Lung; drug effects; metabolism; Platelet-Derived Growth Factor; metabolism; Proto-Oncogene Proteins c-sis; Pulmonary Fibrosis; chemically induced; drug therapy; metabolism; Rats
- From: China Journal of Chinese Materia Medica 2008;33(22):2666-2670
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect and mechanism of Gualou Xiebai (GLXB) decoction on pulmonary fibrosis.
METHODPulmonary fibrosis was induced by bleomycin A5 in SD rats. Rats in treatment group were killed after being treated by GLXB by decoction daily for 28 days. The lungs of all rats were harvested for histopathological studies. The contents of platelet-derived growth factor BB (PDGF-BB) in lungs were measured and compared.
RESULTThe contents of PDGF-BB in lungs have increased significantly in model group compared with normal group and treatment group (P<0.05).
CONCLUSIONGLXB decoction could significantly alleviate the increased PDGF-BB expression in lungs of pulmonary fibrosis rats.
