Influence of JDTL injection on inflammatory factors in rat experimental cerebral ischemia.
- Author:
Hong YANG
1
;
Yi-jun ZHAO
;
Yong-yan WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain; drug effects; immunology; Brain Ischemia; drug therapy; immunology; prevention & control; Cytokines; immunology; Disease Models, Animal; Drugs, Chinese Herbal; administration & dosage; Humans; Inflammation Mediators; immunology; Male; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2008;33(23):2817-2820
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo stydy the protective mechanism of Jiedu Tongluo (JDTL) injection on experimental cerebral ischemia.
METHODRadioimmunoassay (RIA) was utilized to identify the content of TNF-alpha and IL1-beta in brain tissue of rats suffered from 6 h and 24 h ischemia with MCAO, Enzyme-linked immunoadsordent assay (ELISA) was used to observe the level of MCP-1 and ICMA-1.
RESULTAfter 6 h and 24 h of ischemia, the increased contents of TNF-alpha, IL1-beta, MCP-1 as well as ICMA-1 was observed. JDTL injection dramatically inhibited the increase of TNF-alpha, IL1-beta after 6 h and 24 h of ischemia.
CONCLUSIONJDTL injection had inhibiting effect on TNF-alpha, IL1-beta, MCP-1 as well as ICMA-1 caused by cerebral ischemia, the result suggested that JDIL injection can protect cerebral tissue from ischemic injury by inhibiting inflammatory factors.
