Comparison of two kinds of methods to prepare Chinese medicine Danggui Buxue formula pellets.
- Author:
Hong-Xia CHEN
1
;
Xiao-Bin JIA
;
Chen-Yi FAN
;
Ya-Fang SHI
;
Hui-Hua WEI
Author Information
1. School of Pharmacy, Jiangsu University, Zhenjiang 212013, China.
- Publication Type:Journal Article
- MeSH:
Chemistry, Pharmaceutical;
methods;
Dosage Forms;
Drug Compounding;
methods;
Drugs, Chinese Herbal;
chemistry
- From:
China Journal of Chinese Materia Medica
2008;33(24):2908-2910
- CountryChina
- Language:Chinese
-
Abstract:
The pellet-preparating theories and processes of two kinds of methods of extrusion-spheronization and fluid-bed coating method were compared. The micromeritic properties, yield and in vitro dissolution of Danggui Buxue pellets prepared by the two methods were determined. Results showed that the Danggui Buxue pellets prepared by extrusion-spheronization were all spheral with smooth surface, the yield of those pellets was higher and in vitro dissolution of those pellets was more satisfactory. So the two kinds of methods were all suitable to prepare Dang-gui-bu-xue pellets, but Extrusion-spheronization was superior to fluid-bed coating method.
