Effect of isopropyl 3-(3,4-dihydroxyphenyl) -2-hydroxypropanoate on rat pulmonary artery smooth muscle.

Jing LI; Xin MA; Wei-jin Zang

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Effect of isopropyl 3-(3,4-dihydroxyphenyl) -2-hydroxypropanoate on rat pulmonary artery smooth muscle.

Author: Jing LI ¹ ; Xin MA ; Wei-Jin ZANG
Author Information

1. Department of Pharmacology, Medical school of Xi'an Jiaotong University, Xi'an 710061, China.
Publication Type:Journal Article
MeSH: Animals; Female; In Vitro Techniques; Male; Muscle Contraction; drug effects; Muscle, Smooth, Vascular; drug effects; physiology; Propionates; pharmacology; Pulmonary Artery; drug effects; physiology; Rats; Rats, Sprague-Dawley
From: China Journal of Chinese Materia Medica 2008;33(24):2942-2945
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the effect of isopropyl 3-(3,4-dihydroxyphenyl)-2- hydroxypropanoate on vascular smooth muscle.
METHODIsolated rat pulmonary artery was perfused and the tension of the vessel was measured, the effect of isopropyl 3-(3, 4-dihydroxyphenyl)-2-hydroxypropanoate on the pulmonary artery precontracted by noradrenaline (NE) and concentration-response curves of 5-hydroxytryptamine (5-HT), endothelin-1 (ET-1), U46619 and KCl was also observed.
RESULTIsopropyl 3-(3,4-dihydroxyphenyl) -2-hydroxypropanoate exerted relaxation effect on the endothelium-intact artery precontracted by NE in a concentration-dependent manner, which was inhibited with denuded endothelium. The right-shift of the concentration-response curves of 5-HT, ET-1, U46619 and KCl.
CONCLUSIONIsopropyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate have relaxation action on rat pulmonary artery in the way of endothelium-dependance, the mechanism of relaxation action by isopropyl 3-(3,4-dihydroxyphenyl) -2-hydroxypropanoate may be related to calcium channels.