Kunjin virus replicon--a novel viral vector.
- Author:
Shihua LI
1
;
Xiaofeng LI
;
E'de QIN
;
Chengfeng QIN
Author Information
1. State Key Laboratory ofPathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
- Publication Type:Journal Article
- MeSH:
Genetic Vectors;
genetics;
Genome, Viral;
Recombination, Genetic;
Replicon;
genetics;
Virus Replication;
physiology;
West Nile virus;
genetics;
metabolism
- From:
Chinese Journal of Biotechnology
2011;27(2):141-146
- CountryChina
- Language:Chinese
-
Abstract:
Viral replicon is a kind of self-replicating viral RNA sourced from viral genome, which contains viral non-structural genes that are critical for viral genome replication with structural proteins deleted or replaced by foreign genes. Kunjin virus is a member of the Flavivirida family, Flavivirus genus, and Kunjin virus replicon is the first and the clearly defined flavivirus replicon. Kunjun virus replicon has been regarded as an excellent viral vector on account of its high expression, lower cytotoxicity and genetic stability. These unique characteristics of kunjin virus replicons make them suitable for the study of viral genome replication, recombinant proteins production, vaccine development and gene therapy. In this article, recent progress in the development, properties and applications of kunjin virus replicon system was briefly reviewed.
