Fish interferon response and its molecular regulation: a review.
- Author:
Yibing ZHANG
1
;
Jianfang GUI
Author Information
1. State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China. ybzhang@ihb.ac.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Fish Diseases;
immunology;
virology;
Fish Proteins;
genetics;
metabolism;
Fishes;
immunology;
virology;
Gene Expression Regulation;
Interferons;
genetics;
immunology;
STAT1 Transcription Factor;
metabolism;
Virus Diseases;
immunology;
veterinary
- From:
Chinese Journal of Biotechnology
2011;27(5):675-683
- CountryChina
- Language:Chinese
-
Abstract:
Interferon response is the first line of host defense against virus infection. Recent years have witnessed tremendous progress in understanding of fish innate response to virus infection, especially in fish interferon antiviral response. A line of fish genes involved in interferon antiviral response have been identified and functional studies further reveal that fish possess an IFN antiviral system similar to mammals. However, fish virus-induced interferon genes contain introns similar to mammalian type III interferon genes although they encode proteins similar to type I interferons, which makes it hard to understand the evolution of vertebrate interferon genes directly resulting in a debate on nomenclature of fish interferon genes. Actually, fish display some unique mechanisms underlying interferon antiviral response. This review documents the recent progress on fish interferon response and its molecular mechanism.
