Increased Oxidative Stress Affects the Neonatal Birth Weight in Preeclamptic Patients.
- Author:
Young Ju KIM
1
;
Hye Sook PARK
;
Mi Hye PARK
;
Woo Kyoung KIM
;
Eun Ae PARK
;
Eun Hee HA
;
Yun Chul HONG
;
Namsoo CHANG
;
Myung Geol PANG
Author Information
1. Department of Obstetrics and Gynecology, Ewha Womans University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Homocysteine;
TBARS;
GPX activity;
Preeclampsia;
Oxidative stress;
Birth weight
- MeSH:
Birth Weight*;
Case-Control Studies;
DNA;
Female;
Fetal Development;
Gestational Age;
Glutathione Peroxidase;
Homocysteine;
Humans;
Live Birth;
Logistic Models;
Oxidative Stress*;
Parturition*;
Pre-Eclampsia;
Pregnant Women;
Thiobarbituric Acid Reactive Substances
- From:Korean Journal of Obstetrics and Gynecology
2004;47(4):702-707
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To assess the maternal circulating levels of homocysteine, the thiobarbituric acid reactive substances (TBARS) and the glutathione peroxidase (GPX) activities, and to determine whether or not these markers have any effect on the neonatal birth weight in preeclamptic patients. METHODS: A case control study of 74 normal pregnant women and 47 preeclamptic patients who were hospitalized for delivery and had singleton live births between 2000 and 2002 was conducted. The birth weight, gestational age, and maternal circulating level of homocysteine, the TBARS, the GPX activities, and the antioxidant capacity (GPX/TBARS) were measured. GPX genotyping was done with the maternal DNA samples. The results were analyzed with a Chi-square test, student T-test, and logistic regression analyses. RESULTS: The homocysteine and TBARS levels were significantly higher in the preeclamptic patients than in the pregnant controls (p=0.0098 for homocysteine, p<0.0001 for TBARS). The antioxidant capacity (GPX/TBARS) was significantly lower in the preeclamptic patients than in the pregnant controls (p<0.0001). There were no statistically significant differences in the homocysteine level, the TBARS levels, the GPX activity, the gestational age, and birth weight between the wild type of GPX polymorphism and the variant type of GPX polymorphism (p>0.05). After controlling for the covariates, homocysteine reduced the gestational age (p=0.0035) and reduced the birth weight by 27 g (p=0.0259). CONCLUSION: The levels of the oxidative stress markers (homocysteine and TBARS) are higher and the antioxidant capacity (GPX/TBARS) is lower in preeclampsia patients. Homocysteine significantly reduces the fetal growth rate.
