Effects of leukotriene receptor antagonist on chronic obstructive correction of obstractive pulmonary disease induced pulmonary hypertension.

Xiaoning BU; Chen Wang; Baosen Pang

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Effects of leukotriene receptor antagonist on chronic obstructive correction of obstractive pulmonary disease induced pulmonary hypertension.

Author: Xiaoning BU ¹ ; Chen WANG ; Baosen PANG
Author Information

1. Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing 100020, China. buxini74@sina.com
Publication Type:Journal Article
MeSH: Aged; Female; Hemodynamics; drug effects; Humans; Hypertension, Pulmonary; drug therapy; Leukotriene Antagonists; therapeutic use; Leukotriene E4; urine; Male; Oxygen; metabolism; Pulmonary Disease, Chronic Obstructive; complications; Respiration; drug effects; Tosyl Compounds; therapeutic use
From: Chinese Medical Journal 2003;116(3):459-461
CountryChina
Language:English
Abstract:
OBJECTIVESTo assess the hemodynamic, oxygen-dynamic and ventilative effects of Zafirlukast in chronic obstructive pulmonary disease (COPD) induced chronic cor pulmonale at acute exacerbation stage and the mechanisms of Zafirlukast efficacy.
METHODSEleven cases of chronic cor pulmonale at acute exacerbation were examined using Swan-Ganz catheter and peripheral intra-artery catheter. The hemodynamic, oxygen-dynamic parameters and respiratory rate, plasma endothelium-1 (ET-1) level, and urea leukotriene E(4) (LTE(4)) level were measured before and at the 1st, 3rd, 5th, 7th, 9th, 12th hour after taking 40 mg Zafirlukast orally. Arterial and mixed venous blood gas analyses were done correspondingly.
RESULTSThe average pulmonary arterial pressure (mPAP) and pulmonary vascular resistance index (PVRI) were lowered at the 3rd hour after taking Zafirlukast by 23% and 36.5%, respectively. They returned to the baseline around 12th hour. Respiratory rate decreased significantly within the 3rd-7th hour after taking Zafirlukast. LTE(4) and ET-1 levels lowered at the 3rd hour and showed a positive correlation with change of mPAP.
CONCLUSIONSZafirlukast can reduce mPAP, pulmonary vascular resistance (PVR) and does not affect the ambulatory blood pressure monitoring (ABPM) and oxygenation in cases of chronic cor pulmonale at acute exacerbation stage. Zafirlukast may play a role as an alternative to decrease PAP in COPD patients.