Clinical significance of serum cardiac troponin T in patients with congestive heart failure.
- Author:
Chuncai XUE
1
;
Hongwei YU
;
Ruijie LI
;
Jinshan WO
;
Jiayu CUI
;
Haibin CHENG
;
Hongyun WANG
;
Qinghua GUAN
;
Xiaoxia SUO
;
Rongbo JIA
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Female; Heart Failure; blood; physiopathology; Humans; Male; Middle Aged; Stroke Volume; Troponin T; blood; Ventricular Function, Left
- From: Chinese Medical Journal 2003;116(3):469-471
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo determine whether the level of serum cardiac troponin T (cTnT) was increased in patients with congestive heart failure (CHF).
METHODSThis study consisted of 265 patients with CHF and 75 healthy people. Serum cTnT was measured by electrochemiluminescence immunoassay using an Elecsys 1010 automatic analyzer.
RESULTScTnT concentration was 0.181 +/- 0.536 ng/mL in CHF patients and 0.003 +/- 0.001 ng/mL in controls (P < 0.001). Patients were categorized according to the levels of heart function and left ventricular ejection fraction (LVEF). In the first group consisting of 105 patients with LVEF 35%, cTnT was 0.07 +/- 0.0 5 ng/mL (P < 0.01). In patients with NYHA class I, II, III and IV, cTnT values were 0.062 +/- 0.022 ng/mL, 0.113 +/- 0.121 mg/mL, 0.191 +/- 0.231 mg/ml and 0.384 +/- 0.211 mg/mL, respectively (class I vs class II P > 0.05, class II vs class III P < 0.01, class III vs class IV P < 0.01). A negative correlation was observed between serum cTnT concentration and LVEF in 265 patients with CHF (r = -0.493, P < 0.001).
CONCLUSIONSThis study shows that the level of serum cTnT is increased in patients with CHF and that the increased level indicates the severity of CHF.
