Coagulation and fibrinolytic activity in patients with acute cerebral infarction.
- Author:
Feng LI
1
;
Guibin ZHANG
;
Wenzhou ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Aged; Blood Coagulation; Cerebral Infarction; blood; Female; Fibrin Fibrinogen Degradation Products; analysis; cerebrospinal fluid; Fibrinolysis; Humans; Male; Middle Aged; Plasminogen; analysis; cerebrospinal fluid; Plasminogen Activator Inhibitor 1; blood; cerebrospinal fluid; Tissue Plasminogen Activator; blood; cerebrospinal fluid
- From: Chinese Medical Journal 2003;116(3):475-477
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo measure the concentration of D-dimer (DD), tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1) and plasminogen (PLG) activity in plasma and cerebrospinal fluid in patients with acute cerebral infarction and to investigate their clinical significance.
METHODSThe concentrations of D-dimer, t-PA, and PAI-1 in plasma and cerebrospinal fluid in patients were measured by enzyme-linked immunosorbent assay (ELISA). The PLG biological activity was detected using the chromophore method. The results were compared with those of the controls.
RESULTSThe concentrations of D-dimer, t-PA and PAI-1 in cerebrospinal fluid and plasma in patients with acute cerebral infarction were much higher than those of normal subjects (P < 0.01). Conversely, the level of PLG activity was significantly lower in the patients than in the controls (P < 0.01).
CONCLUSIONHypercoagulability and secondary hyperfibrinolysis exist in patients with acute cerebral infarction.
