Delivery in a Patient with Paroxysmal Nocturnal Hemoglobinuria Successfully Managed with Low Molecular Weight Heparin Therapy.
- Author:
Ho Bin KIM
1
;
Hye Jin CHANG
;
Jeong In YANG
;
Haeng Soo KIM
;
Hee Sug RYU
;
Hyo Chul KIM
Author Information
1. Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea.
- Publication Type:Case Report
- Keywords:
Paroxysmal nocturnal hemoglobinuria;
Low molecular weight heparin;
Pregnancy
- MeSH:
Complement Activation;
Female;
Gestational Age;
Hemoglobinuria, Paroxysmal*;
Hemolysis;
Heparin, Low-Molecular-Weight*;
Humans;
Mortality;
Postpartum Period;
Pregnancy;
Thrombosis
- From:Korean Journal of Obstetrics and Gynecology
2004;47(4):748-751
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Paroxysmal nocturnal hemoglobinura is a very rare acquired clonal hematopoietic cell disorder leading to chronic intravascular hemolysis caused by abnormal complement activation. Pregnancy in a patient with paroxysmal nocturnal hemoglobinuria is often complicated with thrombosis resulting serious materno-fetal morbidity and mortality. A case of successful maintenance of the pregnancy, delivery and postpartum in a woman at gestational age of 37 weeks and 2 days with paroxysmal nocturnal hemoglobinuria managed with prophylactic transfusions and anticoagulation therapy by low molecular weight heparin is presented with a review of literature.