Safety of enteral rehabilitative therapy in rat small bowel transplantation.
- Author:
Xiaoqiao ZHANG
1
;
Jieshou LI
;
Ning LI
;
Xin SHI
;
Yousheng LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cyclosporine; therapeutic use; Immunosuppressive Agents; therapeutic use; Interleukin-2; blood; Intestine, Small; transplantation; Lymphocyte Activation; immunology; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Interleukin-2; immunology; Transplantation, Heterotopic; Transplantation, Homologous
- From: Chinese Medical Journal 2003;116(5):703-707
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo evaluate the safety of enteral rehabilitative therapy in rat small bowel transplantation.
METHODSForty-eight rat recipients of allogeneic heterotopic small bowel transplantation (SD and Wistar) were randomly divided into 4 groups according to the application or not of enteral rehabilitative therapy and cyclosporine A (CsA). The pathological changes of the graft, IL-2 receptor expression in lamina propria lymphocytes, serum IL-2 concentrations, results of spleen lymphocytes transformation test and the IL-2 secretion capacity were determined and compared.
RESULTSEnteral rehabilitative therapy could promote the immune function of the recipient so as to augment the acute rejection. But such effects could be blocked by the commonly used immunosuppressant CsA. Under the immunosuppression of CsA (10 mg.kg(-1).d(-1), i.m.), application of enteral rehabilitative therapy did not induce or aggravate acute rejection.
CONCLUSIONUnder effective immunosuppression, application of enteral rehabilitative therapy is safe in rat small bowel transplantation.
