Decreased renal vitamin K-dependent gamma-glutamyl carboxylase activity in calcium oxalate calculi patients.
- Author:
Junhui CHEN
1
;
Jihong LIU
;
Yongshang ZHANG
;
Zhangqun YE
;
Shaogang WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Calcium Oxalate; metabolism; Carbon-Carbon Ligases; metabolism; Humans; Kidney; enzymology; Kidney Calculi; enzymology; Middle Aged
- From: Chinese Medical Journal 2003;116(4):569-572
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo study the activity of vitamin K-dependent gamma-glutamyl carboxylase in patients with calcium oxalate (CaOx) urolithiasis compared with healthy individuals and to assess its relationship to the renal calcium oxalate urolithiasis.
METHODSRenal parenchymas were harvested from urolithic patients and renal tumor patients undergoing nephrectomy. The renal carboxylase activity was evaluated as the radioactivity of [(14)C] labeled sodium bicarbonate in carboxylic reactions in vitro using beta-liquid scintillation counting.
RESULTSSignificantly reduced activity of renal vitamin K-dependent gamma-glutamyl carboxylase was observed in the urolithic group as compared with normal controls (P < 0.01).
CONCLUSIONIt suggests that the reduced carboxylase activity observed in the urolithic patients may play an important role in the course of renal calcium oxalate urolithiasis.
