Optimal extraction of Dingxiang jiangqi granules.
- Author:
Li-Hong ZHANG
1
;
Yan FU
;
Zhi-Rong ZHANG
;
Jian-Xin WANG
;
Shu-Ying MA
;
Sheng-Liang ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Berberine Alkaloids; analysis; Drug Combinations; Drugs, Chinese Herbal; chemistry; isolation & purification; pharmacology; Esophagitis, Peptic; drug therapy; pathology; Esophagus; drug effects; pathology; Flavanones; analysis; Male; Phytotherapy; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Sprague-Dawley; Syzygium; chemistry; Technology, Pharmaceutical; methods
- From: China Journal of Chinese Materia Medica 2007;32(21):2252-2255
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo screen and optimize the extraction of Dingxiangjiangqi granules.
METHODThe extraction route was screened by using pharmacodynamic experiment and the extraction conditions were optimized by orthogonal design and taking extract yield, content of naringin and tetrahydropalmatine as indexes.
RESULTThe pharmacodynamic result showed that aqueous extract had the best effect to cure the esophagitis of rats and the optimized extraction technique was adding 12 times water, extracting 0. 5 hour for 3 times.
CONCLUSIONThe optimum extraction was simple, reasonable, stable and useful for further development.
