Improvement effects of Jincao tablet on immune function of model of hysteromyoma in rats.
- Author:
Jian-Rong LI
1
;
Lan-Sheng WU
;
Guang-Ping ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Ajuga; chemistry; Animals; CD3 Complex; blood; CD4 Antigens; blood; CD4-CD8 Ratio; CD8 Antigens; blood; Drug Therapy, Combination; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacology; Estradiol; blood; Female; Flow Cytometry; Leiomyoma; blood; immunology; pathology; Phytotherapy; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; blood; Tablets; Uterine Neoplasms; blood; immunology; pathology
- From: China Journal of Chinese Materia Medica 2007;32(21):2277-2281
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the improvement effects of Jincao tablet on immune function of the model of hysteromyoma in rat and the relationship between the model and pathogenesis.
METHODRats were randomly divided into 6 groups: normal group, model group, treatment groups including low,middle and high dosage groups of Jincao tablet and Guizhi Fuling pill. Rats were injected respectively with diethyl stilbestrol and progesterone. The immune apparatus of rats were measured. The levels of CD3, CD4 and CD4/ CD8 in serum were determined by flow cytometer. The estrogen and receptor were measured by radioligand binding assay and pathologic changes of womb tissue were observed microscopically.
RESULTCompared with normal group, the weight of thymus, the levels of CD3, CD4 and CD4/CD8 of model group were significantly decreased, and the levels of estrogen, estrogen receptor and CD8 were obviously increased. Jincao tablet groups were significant difference compared with model group and could alleviate the pathological changes of womb tissue.
CONCLUSIONJincao tablet could improve the levels of immune function of the model of hysteromyoma in rat, and it might play a role in the pathogenesis of leiomyoma.
