Screening of effective fraction on experimental gastric ulcer from Pongamia pinnata roots.
- Author:
Ke-Yun LIU
1
;
Yi ZHU
;
Guo-Biao CHEN
;
Zhi DONG
;
Yu-Mei ZHAO
;
Bei LI
;
Chun LIU
;
Jing LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Ulcer Agents; isolation & purification; pharmacology; therapeutic use; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; isolation & purification; pharmacology; therapeutic use; Ethanol; Female; Gastric Mucosa; drug effects; pathology; Male; Mice; Millettia; chemistry; Phytotherapy; Plant Roots; chemistry; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Sprague-Dawley; Reserpine; Stomach Ulcer; chemically induced; pathology; prevention & control
- From: China Journal of Chinese Materia Medica 2007;32(21):2286-2288
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of extract from Pongamia pinnata roots on experimental gastric ulcer and screen the effective fraction.
METHODThe models of gastric mucosa damage were induced by absolute alcohol in rats and reserpine in mice to observed the effect of ethyl alcohol extract from P. pinnata roots (PRE) and different parts on experimental gastric ulcer.
RESULTPRE, acetic ether extract and n-butanol extract could significantly inhibit the gastric mucosa damage induced by absolute alcohol in rats and reserpine in mice. In absolute alcohol models the gastric ulcer rates of inhibition were 86.4%, 85.4%, 11.5%, respectively. In reserpine models the gastric ulcer rates of inhibition were 37.8%, 33.8%, 19.7%, respectively.
CONCLUSIONPRE, acetic ether extract and n-butanol extract could significantly inhibit the gastric mucosa damage induced by absolute alcohol in rats and reserpine in mice. Acetic ether extract from P. pinnata roots has the best effect on experimental gastric ulcer.
