Study on preparation of phenols gastric floating tablet.

Author: Xiao-Ling ZHAI ¹ ; Jian NI ; Yu-Long GU
Author Information

1. Beijing University of Traditional Chinese Medicine, Beijing 100102, China.
Publication Type:Journal Article
MeSH: Drug Carriers; Excipients; chemistry; Gastrointestinal Agents; chemistry; Phenols; chemistry; Polymethacrylic Acids; chemistry; Tablets; Technology, Pharmaceutical; methods
From: China Journal of Chinese Materia Medica 2008;33(1):31-34
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo study the preparation of phenols gastric floating tablet.
METHODThe tablets which were prepared using Eudragit IV, HPMC(K4M), MCC101 and Octadecanol as excipients were evaluated by vitro floatation and releasing performance. The pressure of preparationg was also study to select the optimal preparation.
RESULTThe tablets were successfully prepared in which the drug, Eudragit IV, Octadecanol were 31% respectively,and MCC101 was 7%. And 3-4 kg was found to be the eligible pressure.
CONCLUSIONThe study was found to be effective in the process of phenols gastric floating tablet.