Studies on absorption kinetics of paeonol and paeonol-beta-CD in rat's intestines.
- Author:
Rong-Feng HU
1
;
Cheng-Wu FANG
;
Ai-Feng ZOU
;
Kang-Kang MEI
;
Ji-Hui TANG
;
Ling-Ling HAN
Author Information
1. Department of Pharmaceutics, Anhui College of Traditional Chinese Medicine, Hefei 230038, China. hurongfeng@163.com
- Publication Type:Journal Article
- MeSH:
Acetophenones;
pharmacokinetics;
Animals;
Intestinal Absorption;
physiology;
Intestines;
metabolism;
Kinetics;
Male;
Rats;
Rats, Sprague-Dawley
- From:
China Journal of Chinese Materia Medica
2008;33(1):35-37
- CountryChina
- Language:Chinese
-
Abstract:
To explore the absorption mechanism of paeonol-beta-CD from various intestinal segments and offer biopharmaceutics data for paeonol new dosage form. The absorption kinetics and permeability rate consatants were investigated by the in situ perfusing method in rats. The absorption of the drug conforms to the firt-order kinetics and passive transport mechanism . The results indicate that paeonol-beta-CD absorption mechanism wasn't change.
