Studies on separation, appraisal and the biological activity of 5-HMF in Cornus officinalis.
- Author:
Xia DING
1
;
Ming-Yan WANG
;
Zong-Liang YU
;
Wei HU
;
Bao-Chang CAI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cells, Cultured; Cornus; chemistry; Endothelial Cells; drug effects; Female; Furaldehyde; analogs & derivatives; chemistry; isolation & purification; pharmacology; Liver; drug effects; Male; Mice; Random Allocation
- From: China Journal of Chinese Materia Medica 2008;33(4):392-484
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo develop the mechanism of improving protection function of prepared Cornus officinalis for liver and kidney and the biological activity of 5-hydroxymethylfurfural (5-HMF).
METHODPharmacological and chemical studies were used to choose active part. A compound from active part was separated and appraised. To investigate his biological functions, pharmacological experiment was actualized.
RESULTA component was separated and identified. His is 5-HMF. 5-HMF can protect human vein epidermal cell against H2O2 and glucose and inprove acute liver injury in mice.
CONCLUSION5-HMF is the active component in prepared Cornus officinalis and substance basis for protecting liver and kidney.
