New neolignan from seed of Myristica fragrans.
- Author:
Xiu-Wei YANG
1
;
Xin HUANG
;
Mamat AHMAT
Author Information
- Publication Type:Journal Article
- MeSH: Benzofurans; chemistry; isolation & purification; Benzyl Compounds; chemistry; isolation & purification; Dioxolanes; chemistry; isolation & purification; Eugenol; analogs & derivatives; chemistry; isolation & purification; Lignans; chemistry; isolation & purification; Magnetic Resonance Spectroscopy; Molecular Structure; Myristica fragrans; chemistry; Pyrogallol; analogs & derivatives; chemistry; isolation & purification; Safrole; chemistry; isolation & purification; Seeds; chemistry
- From: China Journal of Chinese Materia Medica 2008;33(4):397-402
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the chemical constituents in the nutmeg (seed of Myristica fragrans).
METHODThe chemical constituents were isolated by various column chromatographic methods and structurally elucidated by IR, NMR and MS evidences.
RESULTFifteen compounds were obtained and identified as myristicin (1), methyleugenol (2), safrole (3), 2, 3-dihydro-7-methoxy-2(3, 4-methylenedioxyphenyl)-3-methyl-5-(E) -propenyl-benzofuran (4), dehydrodiisoeugenol (5), 2, 3-dihydro-7-methoxy-2-(3-methoxy-4, 5-methylenedioxyphenyl) -3-methyl-5-(E)-propenyl-benzofuran (6), erythro-2-(4-allyl-2, 6-dimethoxyphenoxy)-1-(3, 4-dimetho- xyphenyl) propane (7), erythro-2-(4-allyl-2, 6-dimethoxyphenoxy)-1-(3, 4, 5-trimethoxyphenyl) propane (8), erythro-2-(4-allyl-2, 6-dimethoxyphenoxy)-1-(3, 4-dimethoxyphenyl) propan-1-ol acetate (9), erythro-2-(4-allyl-2, 6-dimethoxyphenoxy)-1-(3, 4-dimethoxyphenyl) propan-1-ol (10), erythro-2-(4-allyl-2, 6-dimethoxyphenoxy)-1-(3, 4, 5-trimethoxyphenyl) propan-1-ol (11), 5-methoxy-dehydrodiisoeugenol (12), erythro-2-(4-allyl-2, 6-dimethoxyphenoxy)-1-(4-hydroxy-3-methoxyphenyl)-propan-1-ol (13), guaiacin (14) and threo-2-(4-allyl-2, 6-dimethoxyphenoxy)-1-(3-methoxy-5-hydroxy-phenyl) propan-1-ol (15).
CONCLUSIONCompound 15 is a new compound and named myrisisolignan. Compound 7 is isolated from the genus Myristica for the first time.
