Association of 5-HTTLPR, DRD4 gene polymorphisms with the accident tendentiousness of drivers.
- Author:
Xiao-min WANG
1
;
Li YANG
;
Hai-ying ZHANG
;
Yong LIU
;
Zheng-hua TANG
;
Jian WANG
;
Yan-yan ZHENG
;
Kai-Yong HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Accidents, Traffic; statistics & numerical data; Adult; Automobile Driving; Case-Control Studies; Genotype; Humans; Male; Personality; genetics; Polymorphism, Genetic; Receptors, Dopamine D4; genetics; Serotonin Plasma Membrane Transport Proteins; genetics
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2012;30(7):497-500
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between 5-HTTLPR and/or DRD4 gene polymorphisms and the accident tendentiousness of drivers.
METHODSA case-control study, including 42 patients and 46 controls, were performed using type-A behavior questionnaire and EPQ scale. 5-HTTLPR and DRD4 gene -521 C/T were detected by the PCR-RFLP technique.
RESULTSThe scores of type-A behavior questionnaires, such as TH and TH + CH in exposure group were significantly higher than those in control group (P < 0.05). P and N scores of EPQ questionnaires in exposure group were significantly higher than those in control group, and L score in exposure group was significantly lower than that in control group (P < 0.05 or P < 0.01). There were significant differences in the frequencies of the genotypes and alleles of 5-HTTLPR gene between the cases and the controls (P < 0.05), but there were no significant differences in the frequencies of the genotypes and alleles of DRD4 gene between the two groups (P > 0.05). In the drivers with the accident tendentiousness, P scores in the cases with homozygous genotypes of the S/S in 5-HTTLPR gene were significantly higher than those in the cases with the genotypes of S/L and L/L in 5-HTTLPR gene (P > 0.05). E scores in subjects with homozygous genotypes of the T/T in DRD4 gene were significantly higher than those in subjects with genotypes of the T/C+C/C in DRD4 gene (P > 0.05).
CONCLUSIONThe driver accident tendentiousness may be associated with 5-HTTLPR gene, but not associated with DRD4 gene. The two genes are associated with the type-A behavior and personality characteristics of drivers with accident tendentiousness. However, 5-HTTLPR and DRD4 gene may not have synergism in these behaviors and personality.