Determination of methyl isocyanate (MIC) in air of workplaces by HPLC.
- Author:
Li-qun SONG
1
;
Yang YU
;
Xiao-yun WANG
Author Information
- Publication Type:Journal Article
- MeSH: Air Pollutants, Occupational; analysis; Chromatography, High Pressure Liquid; methods; Environmental Monitoring; methods; Isocyanates; analysis; Workplace
- From:Chinese Journal of Industrial Hygiene and Occupational Diseases 2012;30(8):618-620
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish the method of detecting the concentrations of methyl isocyanate (MIC) in air of workplaces with high performance liquid chromatographic (HPLC).
METHODSSamples are collected by XAD-7 tubes coated with 1-(2-pyridyl) piperazine (1-2PP). Samples are desorbed with acetonitrile (ACN) and analyzed by high performance liquid chromatography (HPLC) using a fluorescence detector.
RESULTSThere was a linear relationship within the range of 0.01 ∼ 10 µg/ml, and the detection limit was 5.3×10(-4) µg/ml. The minimum detectable concentration was 0.01 µg/ml, and the lowest detected concentration was 3.3×10(-3) mg/m(3). The relative standard deviation was 2.2% ∼ 5.3%. The average desorption efficiency was 90% and the sampling efficiencies were 100%. The samples could be stored for 10 days in cold storage condition.
CONCLUSIONThe present method could meet with the requirements of Guide for establishing occupational health standards-Part4 Determination methods of air chemicals in workplace and be feasible for determination of MIC in workplace air.
