Protective Effect of Etomidate on Kainic Acid-induced Neurotoxicity in Rat Hippocampus.
10.4097/kjae.2001.40.6.794
- Author:
Eun Ju LEE
1
;
Joung Uk KIM
;
Mi Jeung GWAK
;
Sung Min HAN
;
Jong Whan LEE
;
Hee Nam HONG
;
Donghou KIM
Author Information
1. Departments of Anesthesiology and *Anatomy, College of Medicine, University of Ulsan, Korea.
- Publication Type:Original Article
- Keywords:
Anesthetics, intravenous: etomidate;
Animals: rats;
Brain: hippocampus;
Protein: heat shock protein-70;
Toxicity: Kainic acid;
neurotoxicity
- MeSH:
Animals;
Cell Death;
Etomidate*;
Hippocampus*;
Hot Temperature;
Kainic Acid;
Neurons;
Neuroprotective Agents;
Rats*;
Rosaniline Dyes;
Shock
- From:Korean Journal of Anesthesiology
2001;40(6):794-801
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The present investigation was undertaken to evaluate the neuroprotective effect of etomidate against kainic acid (KA) induced neurotoxicity in rats by using the immunoreactivity of heat shock protein-70 (HSP-70) and the acid-fuchsin stain. METHODS: Administration of etomidate (20 mg/kg, I.P.) was performed in sequence; first being just one hour after a KA (10 mg/kg, I.P.) injection, then three more times at one hour intervals. Neuronal damages in the hippocampus were evaluated by using the acid-fuchsin stain to detect cell death and HSP-70 induction as an index of cell injury at 24 h after the administration of KA. RESULTS: HSP-70 induction and acid fuchsin positive neurons were increased in the CA1 and CA3 regions of the hippocampus after a KA injection but significantly decreased by an injection of etomidate (P < 0.01). CONCLUSIONS: These results suggest that the etomidate has a potential effect on the protection of neurons against KA-induced neurotoxicity.
