Research development of the induced animal model of osteoarthritis.
- Author:
Yan SHEN
1
;
Hong-ting JIN
;
Pei-jian TONG
;
Lu-wei XIAO
Author Information
1. Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, Zhejiang, China. louissy@163.com
- Publication Type:Journal Article
- MeSH:
Animals;
Biomedical Research;
Disease Models, Animal;
Humans;
Osteoarthritis;
drug therapy;
pathology;
physiopathology;
surgery
- From:
China Journal of Orthopaedics and Traumatology
2008;21(9):716-718
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis (OA) is a retrogressive arthrosis of which incidence rate increased obviously with the age. Accompany with the aging of the population, the incidence of this disease appeares an upward trend significantly. The etiology and pathogenesis of AO is not very clear at present, so it's important to establish animal models for discussing the pathogenesis of AO and searching reasonable ways to diagnose and treat. The induced animal model is used more commonly, it includes non-operation ways and operation ways, the former includes drug injection, joint immobilization, transarticular impact, etc.; the latter includes destroy the stability of joint, change the stress of joint, snick on condylofemur etc. This article makes a brief review on those questions, looks forward to providing some reference on choosing OA animal model correctly and reasonably.
