Impact of antihypertensive medication timing on degree and stability of blood pressure lowering in patients with essential hypertension
10.3760/cma.j.issn.0253-3758.2009.11.016
- VernacularTitle:不同服药方法对高血压患者降压有效性和平稳性的影响
- Author:
Chun-Ling MU
1
;
Cui-Ping ZHAO
;
Jie-Ning HOU
;
Li-Si JIANG
;
Tong-Qiang CUI
;
Bing BAI
Author Information
1. 哈尔滨医科大学附属第一医院
- Keywords:
Hypertension;
Select time take medicine;
Treatment outcome
- From:
Chinese Journal of Cardiology
2009;37(11):1010-1013
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of antihypertensive medication timing on degree and stability of blood pressure (BP) lowering in patients with moderate and severe essential hypertension. Methods Ninety patients were randomly assigned to take Valsartan and Felodiping together in the morning (group A), Valsartan in the morning and Felodiping in the evening (group B) or Felodiping in the morning and Valsartan in the evening (group C, n=30 each). The morning dosage was titrated if the goal blood pressure was not achieved. Ambulatory blood pressure monitoring (ABPM) was performed on the first and 14~(th) day of medication. Results The BP reductions during nighttime and twenty-four in group B and C hours were similar (P>0.05) but were significant more than those in group A (P<0.05). The smoothness indexes of mean systolic, mean arterial blood pressure during nighttime and twenty-four in group B and C were similar but significantly higher than that in group A (P<0.05). The smoothness index of diastolic pressure at nighttime in group B and C was similar but signifieantly higher than that in group A (P<0.05). Conclusion More significant and stable antihypertensive effects could be achieved by taking the two antihypertensive medications separately in the morning and at evening compared that taken the two drugs together in the morning.
