Efficacy of cardiac resynchronization therapy for patients with refractory congestive heart failure
10.3760/cma.j.issn.0253-3758.2009.10.005
- VernacularTitle:31例难治性慢性心力衰竭心脏再同步化治疗的疗效观察
- Author:
Hu-Yati MU
1
;
Tao LIN
;
Yi-Tong MA
;
Bao-Peng TANG
;
Xue-Kun SHI
;
Zhi-Qiang LIU
Author Information
1. 新疆医科大学附属第一医院
- Keywords:
Heart failure;
congestive;
Cardiac pacing;
artificial;
Defibrillators;
implantable
- From:
Chinese Journal of Cardiology
2009;37(10):878-882
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy of cardiac resynchronization therapy for patients with refractory congestive heart failure. Methods Thirty-one patients with refractory congestive heart failure received cardiac resynchronization therapy. Before operation, all patients received standard drug therapy (28 cases) or integrated with CRRT (3 cases). Coronary sinus and its branches were shown by direct angiography with hollow angiographic catheter(11 cases)and by balloon angiographic catheter (20 cases). Left ventricle and right ventricle electrodes were implanted to 3 patients with atrial fibrillation, 4 patients with paroxysmal ventricular tachycardia or ventricular fibrillation received CRT-D implantation. electrocardiogram, 24 hours Holter, echocardiography and physical clinical examinations were made at baseline, 6, 12,18 and 24 months post resynchronization therapy. Results Pacemakers were successfully implanted in all 31 patients. One patient implanted with CRT-D died of multiple organ failure on third day after operation, 1 patient suffered sudden cardiac death 5 months after therapy and 2 patients were lost to fellow up 6 and 12 months after operation, respectively. Results from the remaining 27 patients showed that QRS duration was significantly decreased ( 153±8.4 at baseline vs. 132±9.8 at 24 months follow up) and cardiac function significantly improved (LVEF 0.29±0.10 at baseline vs. 0.41±0.11 at 24 months follow up, P<0.05 vs. baseline) during follow up compared to baseline. Malignant ventricular arrhythmia occurred in 3 patients with CRT-D and successfully terminated and converted to sinus rhythm. Conclusions Cardiac resynchronization therapy could improve cardiac function for patients with refractory congestive heart failure. CRT-D can effectively terminate the malignant ventricular arrhythmia.
