Increased serum apolipoprotein A5 in patients with acute coronary syndrome
10.3760/cma.j.issn.0253-3758.2009.10.009
- VernacularTitle:急性冠状动脉综合征患者载脂蛋白A5检测及其意义
- Author:
Xian-Sheng HUANG
1
;
Shui-Ping ZHAO
;
Qian ZHANG
;
Lin BAI
;
Min HU
;
Wang ZHAO
Author Information
1. 中南大学湘雅二医院
- Keywords:
Coronary disease;
Apolipoproteins A;
Triglycerides;
C-reactive protein
- From:
Chinese Journal of Cardiology
2009;37(10):896-899
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum apolipoprotein A5 (APOA5) and lipid profile or high sensitive C-reactive protein (hs-CRP) in patients with acute coronary syndrome (ACS). Methods Serum apoA5 and hs-CRP levels were measured by ELISA and immunoturbidimetry in control subjects (n=232), patients with stable angina (SA, n=127), unstable angina (UA, n=116) and acute myocardial infarction (AMI, n=112). Triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were also measured. Results Compared with controls [(108.7±23.2 )μg/L] and SA patients [(78.3±20.2 )μg/L], serum ApoA5 level was significantly increased in UA [(340. 6±63.5)μg/L] and AMI patients [(373.2±73.8) μg/L] ( all P<0.05 ). ApoA5 was positively correlated with TG (r=0.63 and 0.67, respectively, all P<0.05) and hs-CRP (r=0.57 and 0. 55, respectively, all P<0.05) in UA and AMI patients but there were no significant correlations between ApoA5 and TC, HDL-C and LDL-C in ACS patients (all P>0.05). Conclusion Increased serum apoA5 level and the positive correlation between ApoA5 and serum TG and hs-CRP in ACS patients might reflect increased inflammation responses in ACS patients.
