Efficacy of a domestic left-disk-coated atrial septal occluder on treating patent foramen Ovale in a miniswine model
10.3760/cma.j.issn.0253-3758.2009.10.018
- VernacularTitle:左盘外包膜房间隔封堵器治疗卵圆孔未闭的实验研究
- Author:
Yi-Gao HUANG
1
;
Cao-Jin ZHANG
;
Tao HUANG
;
Wen-Hui HUANG
;
Xin-Sheng HUANG
Author Information
1. 广东省心血管病研究所
- Keywords:
Heart septal defects;
atrial;
Heart catheterization
- From:
Chinese Journal of Cardiology
2009;37(10):936-938
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of domestic left-disk-coated atrial septal occluder on treating patent foramen ovale in a miniswine model. Methods Foramen ovale was punctured in 12 Guangxi BA-MA miniswine and occluded by domestic left-disk-coated atrial septal occluder (Spider~(TM) PFO closure system) under the guidance of fluoroscopy. After occlusion, miniswine were executed after transthoracic echocardiography examination with color Doppler at month 1, 2,3 and 6 respectively for gross inspection and microscopic examinations. Results There were no vegetation, thrombosis, broken stent, or erosion on the surface of all devices. The PFOs were completed occluded as evidenced by transthoracic echocardiography at 1 to 6 months after operation. The surface of the device was fully covered by collagen tissue and endothelial tissue at 1 month after operation and the thickened gradually thereafter. Conclusions The domestic left-disk-coated atrial septal occluder can efficiently occlude patent foramen ovale. Satisfactory biocompatibility, rapid and complete endothelium covering and low incidence of complication are also evidenced for this closure system in our experiment.
