The effect of the bases and added substances on the release and absorption of sodium diclofenac from its different ointment formulations
- Author:
Long Van Nguyen
- Publication Type:Journal Article
- Keywords:
sodium diclofenac
- MeSH:
Diclofenac;
Ointments
- From:Journal of Medical and Pharmaceutical Information
1999;(6):26-29
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The effect of the bases and added substances on the release and absorption of sodium diclofenac from its different ointment formulations was studied. The results shown that the released extent of sodium diclofenac from different ointment bases across dialysis membrane was following the order: water soluble bases > emulsion bases > emugel bases > hydrocarbon bases and carbopol 934 gel with 1.2% I-menthol > carbopol 934 gel with 0.5% I-menthol > carbopol 934 gel with 3% oleic acid > carbopol 934 gel only. The percutaneous absorbed extent of sodium diclofenac across the rat hairless skin was evaluated indirectly based on antiinflammatory action on the rat leg stimulated edema by 0.1 ml of 1% caragenin solution. The average reduced percent of leg edema volume of the experimented rat group was obtained in such order: carbopol 934 gel with 1.2% I-menthol > carbopol 934 gel with 0.5% I-menthol > carbopol 934 gel with 3% oleic acid > carbopol 934 gel only. This result demonstrated that there was a correlation between in vitro release and in vivo percutaneous absorption of sodium diclofenac through the rat hairless skin.
