Plasma proteomic analysis In male normotensive, prehypertensive and hypertensive subjects

VernacularTitle:男性高血压前期与正常血压及原发性高血压患者血浆比较蛋白质组学研究
Author: Zuo-Guang WANG ¹ ; Yan-Duo TAO ; Ya LIU ; Jie-Lin LIU ; Xin-Jun CHEN ; Jie WEN ; Shao-Jun WEN ; Zhao-Su WU
Author Information

1. 北京市心肺血管疾病研究所首都医科大学附属北京安贞医院
Keywords: Hypertension; Proteomics
From: Chinese Journal of Cardiology 2010;38(1):5-10
CountryChina
Language:Chinese
Abstract: Objective To compare the plasma proteome among male normotensive, prehypertensive, and hypertensive subjects. Methods Plasma proteome was analyzed by two-dimensional electrophoresis combined with MALDI-TOF mass spectrometry in this case-control study among well matched male normotensive, prehypertensive and hypertensive subjects (n = 26 each). Results The results showed that there were 22 differentially expressed protein spots among the protein samples derived from the 3 groups which corresponded to 18 proteins associated with inflammation and immunity, lipid metabolism, transport, coagulation and fibrinolysis, cell proliferation and apoptosis, and antioxidation. Conclusion Proteins were differentially expressed in male subjects with various blood pressure levels.