Renal protective effects of benidipine and valsartan in primary hypertension patients with proteinuria
10.3760/cma.j.issn.0253-3758.2010.01.006
- VernacularTitle:贝尼地平和缬沙坦对原发性高血压伴蛋白尿患者肾脏保护作用的对比
- Author:
Tao PENG
1
;
Zhao HU
;
Ling GUO
;
Xiang-Dong YANG
;
Qing XIA
;
Xian-Hua LI
;
Bei JIANG
;
Fei PEI
;
Jian SONG
Author Information
1. 山东大学齐鲁医院
- Keywords:
Hypertension;
Proteinuria;
Calcium channel blockers;
Angiotensin Ⅱ type 1 receptor blockers
- From:
Chinese Journal of Cardiology
2010;38(1):20-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the renal protective effects between calcium channel blocker benidipine and angiotensin Ⅱ receptor blocker valsartan in primary hypertension patients with proteinuria. Methods A total of 236 patients were divided to low (< 1 g/24 h) and high (1-3 g/24 h) proteinuria groups and treated with benidipine (8 mg/d) or valsartan (80 mg/d) for 48 weeks. Blood pressure, glomerular filtration rate(GFR) and 24 h protein were measured at baseline, 12, 24 and 48 weeks. Results Blood pressure was significantly and equally reduced in all treated groups (all P < 0.05 vs. baseline). GFR was also significantly and equally improved in all treated groups after 24 weeks treatments (all P < 0.05 at 24 weeks and 48 weeks). Proteinuria reduction at 24 and 48 weeks was more significant in patients treated with valsartan compared to patients treated with benidipine in low preteinuria group [24 weeks: (0.27±0.07)g/24 h vs. (0.39±0.06)g/24 h, P<0.01; 48 weeks: (0.18±0.01)g/24 h vs. (0.30±0.05) g/24 h, P < 0.01]. Conclusion The renal protection efficacy of vlsartan and banidipine was similar in primary hypertensive patients with proteinuria.
