Association between multi-noninvasive indexes and mild coronary stenosis
10.3760/cma.j.issn.0253-3758.2010.01.009
- VernacularTitle:冠状动脉轻度狭窄患者多种无创性检测指标的变化及意义
- Author:
Li-Gen DU
1
;
Jian OIU
;
Yun-Jun RUAN
;
Feng-Ying DONG
;
Chang-Jiang HONG
;
Jun MA
;
Lin XU
Author Information
1. 广州军区广州总医院
- Keywords:
Coronary atherosclerosis;
Arteries elasticity;
Inflammation
- From:
Chinese Journal of Cardiology
2010;38(1):31-34
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of multi-noninvasive indexes including endothelial function, arterial flexibility, carotid intima-media thickness (IMT) and serum inflammatory cytokines in patients with mild coronary stenosis. Methods One hundred and five patients were divided into three groups according to the result of coronary angiography: coronary heart disease (stenosis ≥ 50% in at least one coronary segment), mild coronary stenosis (stenosis < 50% in at least one coronary segment) and control group (normal coronary). Brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI), reflecting arterial flexibility and the lower extremity vascular disease respectively, were measured by a Colin system, carotid artery IMT was detected echocardiographically. Serum levels of NO, vWF, hs-CRP were measured before coronary angiography in all patients. Results baPWV [(1482±155) cm/s vs. (1249±158)cm/s] and carotid IMT [(0.88±0.18)mm vs. (0.72±0.20) mm] were significantly higher while serum levels of NO [(64±17) μmol/L vs. (83±17) μmol/L] was significantly lower in mild coronary stenosis group than those in control group (all P<0.05). vWF, ABI and hs-CRP were similar between the two groups (all P> 0.05). Logistic regression analysis showed that NO, baPWV, smoking are independent predicting factors for mild coronary stenosis (all P < 0.05) . Conclusions Endothelial dysfunction, reduction of the arterial flexibility as well as increased serum inflammation were associated with mild coronary stenosis.
