Toxicity of matrine in Kunming mice.
- Author:
Xiao-yan WANG
1
;
Lei LIANG
;
Jian-lan CHANG
;
Min-hui YANG
;
Zu-guo LI
Author Information
- Publication Type:Journal Article
- MeSH: Alkaloids; toxicity; Animals; Brain; drug effects; pathology; Female; Lethal Dose 50; Male; Mice; Quinolizines; toxicity; Toxicity Tests, Acute
- From: Journal of Southern Medical University 2010;30(9):2154-2155
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the acute toxicity and assess the median lethal dose (LD50) of matrine in Kunming mice.
METHODSMatrine at different doses were administered in Kunming mice via intraperitoneal injection, and the toxic reactions and LD50 of matrine was observed and determined.
RESULTSThe acute toxicity test of matrine indicated that the tolerable dose of matrine was above 80 mg/kg in Kunming mice, and the LD50 was 157.13 mg/kg (95%CI, 88.08-280.31 mg/kg). Morphological observation revealed degenerative changes of the nerve cells in the brain tissue of the mice.
CONCLUSIONThe nervous system is the main target organ by the toxicity of matrine.
