TrxR2 gene polymorphisms may not be associated with the susceptibility to Kashin-Beck disease.
- Author:
Wei LU
1
;
Xiao-yan MO
;
Yong-min XIONG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alleles; Female; Genetic Predisposition to Disease; Genotype; Humans; Kashin-Beck Disease; genetics; Male; Middle Aged; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Thioredoxin Reductase 2; genetics
- From: Journal of Southern Medical University 2010;30(10):2246-2248
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the association between single nucleotide polymorphisms of thioredoxin reductase-2 (TrxR2) gene and the susceptibility to Kashin-Beck disease (KBD).
METHODSPolymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze the genotype frequencies of rs5748469 in TrxR2 gene in 84 KBD patients and 109 healthy control subjects.
RESULTSThe genotype frequencies of A/A, A/C, and C/C in the KBD patients were 83.33%, 15.48% and 1.19%, as compared with the frequencies of 74.31%, 25.69%, and 0.00% in the healthy control, respectively, showing no significant difference in the single nucleotide polymorphisms of TrxR2 gene between the two groups (P=0.13).
CONCLUSIONNo obvious correlation can be found between rs5748469 polymorphisms in TrxR2 gene and the susceptibility to KBD.
