OBJECTIVETo observe the hemodynamic changes and liver and kidney function variations in pregnant rats with pre-eclampsia after treatment with low-energy laser irradiation.

METHODSForty pregnant SD rats were randomly divided into the experimental group (group A), experimental control group (group B), blank control group (group C) and blank exposure group (group D) (n=10). The rats in groups A and B were injected with 1 µg/kg endotoxin via the tail vein at the 14th day of gestation, and those in groups C and D received normal saline injections. In groups A and B, low-energy laser irradiation of the chest was carried out since day 16 of gestation. Blood pressure, urine protein, liver and kidney function and the hemodynamic changes in the rats were observed.

RESULTSAfter the treatment, blood pressure, urine protein, ALT, BUN and Cr of group A were lower than those of group B (P<0.05), but similar with those in groups C and D (P>0.05). The blood and plasma viscosity and hematocrit of group A were also lower than those of group B (P<0.01), but comparable with those in groups C and D.

CONCLUSIONLow-energy laser irradiation in the chest area may improve the hemodynamic indices, decrease blood pressure and urine protein, and ameliorate liver and kidney functions in pregnant rats with pre-eclampsia.